Sedating antihistamines and

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Interactions with other drugs are more common with first-generation antihistamines compared with second-generation antihistamines.Second generation antihistamines were developed in the 1980s and are much less sedating than first-generation antihistamines.

Thus the 'non-sedating' title of the 2nd generation antihistamines refers to a low tendency to diminish CNS arousal when taken in therapeutic doses.BMJ 2000; 320: 1184-1186 4 O'Hanlon JF, Ramaekers JG.Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-1994.It is unlikely that the majority of patients will experience untoward reactions affecting their driving safety, but if any fraction will, all patients should receive an appropriate warning.JG Ramaekers, Senior researcher and lecturer A0 Vermeeren, Senior researcher and lecturer Experimental Psychopharmacology Unit, Brain & Behaviour Institute, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands 1 Yanai K, Ryu JH, Watanabe T, Iwata R, Ido T, Sawai Y, Ito K, Itoh M.Their prescription-event monitoring study demonstrated that 2nd generation antihistamines differ in their potential to produce sedation.

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